Sr. Scientist, Clinical Bioinformatics
10x Genomics is building a clinical diagnostics division and seeks a senior computational scientist to translate single-cell and spatial transcriptomics into clinically actionable biomarkers and diagnostics. The role requires implementing and optimizing ML and statistical algorithms on some of the largest single-cell biomedical datasets, developing scalable bioinformatics pipelines, and distilling complex biological findings into clinical insights. Requires a PhD in bioinformatics or computational biology with a minimum of 5 years of post-PhD industry experience and deep expertise in single-cell NGS.
Sr. Scientist, Clinical Bioinformatics
Location: Pleasanton, California, USA (HQ)
Company: 10x Genomics
About the Role
10x Genomics is establishing a diagnostics effort, translating their leading single-cell and spatial assay technologies into impactful clinical applications. This Sr. Scientist will work at the intersection of computational biology and clinical diagnostics, deriving insights that power the next generation of molecular diagnostics.
Key Responsibilities
- Distill complex biological questions into actionable computational strategies
- Implement and optimize statistical/ML methods for large-scale single-cell and spatial transcriptomics datasets
- Derive clinically meaningful biomarkers from cutting-edge 10x Genomics data
- Develop high-performance, scalable bioinformatics code
Minimum Requirements
- PhD in bioinformatics, computational biology, genomics, or related discipline
- Minimum 5 years of industry experience post-PhD
- Extensive hands-on experience with large-scale single-cell NGS data analysis
- Proficiency in Linux; in-depth statistical methodology knowledge
Preferred Skills
- Clinical genomics and biomarker discovery experience
- Machine learning applied to single-cell/spatial transcriptomics
- Workflow orchestration: Snakemake, Nextflow, or Martian